The mobility of two kinase domains in the Escherichia coli chemoreceptor array varies with signaling state
نویسندگان
چکیده
Ariane Briegel1, Peter Ames2, James C. Gumbart3, Catherine M. Oikonomou4, John S. Parkinson2, and Grant J. Jensen1,4,* 1California Institute of Technology, 1200 E. California Blvd, Pasadena, CA 91125 2University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 3School of Physics, Georgia Institute of Technology, Atlanta, Georgia 30332 4Howard Hughes Medical Institute, 1200 E. California Blvd, Pasadena, CA 91125
منابع مشابه
The mobility of two kinase domains in the Escherichia coli chemoreceptor array varies with signalling state.
Motile bacteria sense their physical and chemical environment through highly cooperative, ordered arrays of chemoreceptors. These signalling complexes phosphorylate a response regulator which in turn governs flagellar motor reversals, driving cells towards favourable environments. The structural changes that translate chemoeffector binding into the appropriate kinase output are not known. Here,...
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Bacterial chemoreceptors form ternary signaling complexes with the histidine kinase CheA through the coupling protein CheW. Receptor complexes in turn cluster into cellular arrays that produce highly sensitive responses to chemical stimuli. In Escherichia coli, receptors of different types form mixed trimer-of-dimers signaling teams through the tips of their highly conserved cytoplasmic domains...
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تاریخ انتشار 2013